Assay Detail
Binding
CHEMBL4411721
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PHD (unknown origin) expressed in mouse NIH/3T3 cells harboring HRE-driven luciferase gene assessed as transactivation of HIF1alpha after 6 hrs by luciferase reporter gene assay
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Hypoxia-inducible factor prolyl hydroxylase (CHEMBL3831261) ↗| Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
Publication
Triterpenoid Hydroxamates as HIF Prolyl Hydrolase Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 23 | 5.24 | 5.62 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4463388 | — | — | 1 | 5.62 |
| CHEMBL4464252 | — | — | 1 | 5.58 |
| CHEMBL4459542 | — | — | 1 | 5.50 |
| CHEMBL4519581 | — | — | 1 | 5.42 |
| CHEMBL4514184 | — | — | 1 | 5.32 |
| CHEMBL4589866 | — | — | 1 | 5.30 |
| CHEMBL4472548 | — | — | 1 | 5.24 |
| CHEMBL4583726 | — | — | 1 | 5.17 |
| CHEMBL4563191 | — | — | 1 | 5.15 |
| CHEMBL4592450 | — | — | 1 | 5.12 |
| CHEMBL3753400 | — | — | 1 | 5.11 |
| CHEMBL4436329 | — | — | 1 | 5.05 |
| CHEMBL4562991 | — | — | 1 | 4.94 |
| CHEMBL3754102 | — | — | 1 | 4.79 |
| CHEMBL1271303 | — | — | 1 | - |
| CHEMBL4064111 | — | — | 1 | - |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | - |
| CHEMBL201515 | MASLINIC ACID | — | 1 | - |
| CHEMBL269277 | BETULINIC ACID | 1.0 | 1 | - |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
| CHEMBL4460360 | — | — | 1 | - |
| CHEMBL4473530 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4463388 | — | EC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4464252 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4459542 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4519581 | — | EC50 | = | 3800.0 | nM | 5.42 |
| CHEMBL4514184 | — | EC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4589866 | — | EC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4472548 | — | EC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL4583726 | — | EC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4563191 | — | EC50 | = | 7100.0 | nM | 5.15 |
| CHEMBL4592450 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL3753400 | — | EC50 | = | 7700.0 | nM | 5.11 |
| CHEMBL4436329 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL4562991 | — | EC50 | = | 11400.0 | nM | 4.94 |
| CHEMBL3754102 | — | EC50 | = | 16400.0 | nM | 4.79 |
| CHEMBL1271303 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4064111 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL230006 | ENOXOLONE | EC50 | > | 50000.0 | nM | - |
| CHEMBL201515 | MASLINIC ACID | EC50 | > | 50000.0 | nM | - |
| CHEMBL269277 | BETULINIC ACID | EC50 | > | 50000.0 | nM | - |
| CHEMBL169 | URSOLIC ACID | EC50 | > | 50000.0 | nM | - |
| CHEMBL168 | OLEANOLIC_ACID | EC50 | > | 50000.0 | nM | - |
| CHEMBL4460360 | — | EC50 | > | 50000.0 | nM | - |
| CHEMBL4473530 | — | EC50 | > | 50000.0 | nM | - |