Assay Detail
Functional
CHEMBL4411822
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Cytotoxicity against human A549/TR cells expressing NQO1 assessed as reduction in cell viability after 72 hrs by MTT assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549/TR |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Nonquinone Substrates for NAD(P)H: Quinone Oxidoreductase 1 (NQO1) as Effective Intracellular ROS Generators for the Treatment of Drug-Resistant Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 17 | 5.57 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4573425 | — | — | 1 | 6.22 |
| CHEMBL3589013 | — | — | 1 | 6.22 |
| CHEMBL4462343 | — | — | 1 | 6.10 |
| CHEMBL4464481 | — | — | 1 | 6.05 |
| CHEMBL4592916 | — | — | 1 | 5.89 |
| CHEMBL15192 | LAPACHONE | 2.0 | 1 | 5.72 |
| CHEMBL4442330 | — | — | 1 | 5.66 |
| CHEMBL4444518 | — | — | 1 | 5.62 |
| CHEMBL4584162 | — | — | 1 | 5.57 |
| CHEMBL4569978 | — | — | 1 | 5.54 |
| CHEMBL4555260 | — | — | 1 | 5.39 |
| CHEMBL4580655 | — | — | 1 | 5.31 |
| CHEMBL4550273 | — | — | 1 | 5.29 |
| CHEMBL4440741 | — | — | 1 | 5.20 |
| CHEMBL4515695 | — | — | 1 | 5.17 |
| CHEMBL4563883 | — | — | 1 | 5.17 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 4.57 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4573425 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL3589013 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4462343 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4464481 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4592916 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL15192 | LAPACHONE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4442330 | — | IC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4444518 | — | IC50 | = | 2400.0 | nM | 5.62 |
| CHEMBL4584162 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4569978 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL4555260 | — | IC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL4580655 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4550273 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4440741 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL4515695 | — | IC50 | = | 6800.0 | nM | 5.17 |
| CHEMBL4563883 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 27000.0 | nM | 4.57 |