Assay Detail
ADMET
CHEMBL4411980
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Negative inotropic activity in guinea pig spontaneously beating spontaneously beating right atrium assessed as decrease in developed tension
8
Total Activities
8
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Tissue | Right cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 8 | 5.85 | 6.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590632 | — | — | 1 | 6.33 |
| CHEMBL4449273 | — | — | 1 | 6.29 |
| CHEMBL514508 | — | — | 1 | 5.97 |
| CHEMBL4573134 | — | — | 1 | 5.73 |
| CHEMBL4577064 | — | — | 1 | 5.66 |
| CHEMBL4574696 | — | — | 1 | 5.66 |
| CHEMBL475745 | — | — | 1 | 5.61 |
| CHEMBL4549511 | — | — | 1 | 5.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590632 | — | EC50 | = | 470.0 | nM | 6.33 |
| CHEMBL4449273 | — | EC50 | = | 510.0 | nM | 6.29 |
| CHEMBL514508 | — | EC50 | = | 1080.0 | nM | 5.97 |
| CHEMBL4573134 | — | EC50 | = | 1870.0 | nM | 5.73 |
| CHEMBL4577064 | — | EC50 | = | 2180.0 | nM | 5.66 |
| CHEMBL4574696 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL475745 | — | EC50 | = | 2480.0 | nM | 5.61 |
| CHEMBL4549511 | — | EC50 | = | 2870.0 | nM | 5.54 |