Assay Detail
ADMET
CHEMBL4411985
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Negative inotropic activity in guinea pig left atrium assessed as decrease in developed tension
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Cavia porcellus |
| Tissue | Left cardiac atrium |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Polycyclic maleimide-based derivatives as first dual modulators of neuronal calcium channels and GSK-3β for Alzheimer's disease treatment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 10 | 6.10 | 6.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4590632 | — | — | 1 | 6.66 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 6.58 |
| CHEMBL4558734 | — | — | 1 | 6.50 |
| CHEMBL475745 | — | — | 1 | 6.37 |
| CHEMBL4549511 | — | — | 1 | 6.07 |
| CHEMBL514508 | — | — | 1 | 6.06 |
| CHEMBL4574696 | — | — | 1 | 5.83 |
| CHEMBL4449273 | — | — | 1 | 5.72 |
| CHEMBL4573134 | — | — | 1 | 5.72 |
| CHEMBL4577064 | — | — | 1 | 5.44 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4590632 | — | EC50 | = | 220.0 | nM | 6.66 |
| CHEMBL193 | NIFEDIPINE | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL4558734 | — | EC50 | = | 320.0 | nM | 6.50 |
| CHEMBL475745 | — | EC50 | = | 430.0 | nM | 6.37 |
| CHEMBL4549511 | — | EC50 | = | 850.0 | nM | 6.07 |
| CHEMBL514508 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4574696 | — | EC50 | = | 1490.0 | nM | 5.83 |
| CHEMBL4449273 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4573134 | — | EC50 | = | 1910.0 | nM | 5.72 |
| CHEMBL4577064 | — | EC50 | = | 3650.0 | nM | 5.44 |