Assay Detail
Functional
CHEMBL4412031
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Antiproliferative activity against human Bel7402 cells after 72 hrs by MTT assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Bel-7402 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis and biological evaluation of quinoline-indole derivatives as anti-tubulin agents targeting the colchicine binding site.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.52 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437037 | — | — | 1 | 8.00 |
| CHEMBL67 | COMBRETASTATIN A4 | -1.0 | 1 | 7.96 |
| CHEMBL4474171 | — | — | 1 | 7.55 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | 4.0 | 1 | 6.56 |
| CHEMBL90555 | VINCRISTINE | 4.0 | 1 | - |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437037 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL67 | COMBRETASTATIN A4 | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4474171 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL359744 | DOXORUBICIN HYDROCHLORIDE | IC50 | = | 274.0 | nM | 6.56 |
| CHEMBL90555 | VINCRISTINE | IC50 | - | — | - | |
| CHEMBL428647 | PACLITAXEL | IC50 | - | — | - |