Assay Detail
Functional
CHEMBL4412206
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Antiproliferative activity against human A549 cells harboring KRAS G12S point mutant after 72 hrs by SRB assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Fragment-based drug discovery of triazole inhibitors to block PDEδ-RAS protein-protein interaction.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 4.76 | 5.19 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3286929 | — | — | 1 | 5.19 |
| CHEMBL4450839 | — | — | 1 | 4.99 |
| CHEMBL4527667 | — | — | 1 | 4.95 |
| CHEMBL4439169 | — | — | 1 | 4.77 |
| CHEMBL4443518 | — | — | 1 | 4.74 |
| CHEMBL4459864 | — | — | 1 | 4.71 |
| CHEMBL4566147 | — | — | 1 | 4.69 |
| CHEMBL4449262 | — | — | 1 | 4.62 |
| CHEMBL4536719 | — | — | 1 | 4.49 |
| CHEMBL4514611 | — | — | 1 | 4.44 |
| CHEMBL4555739 | — | — | 1 | - |
| CHEMBL4532027 | — | — | 1 | - |
| CHEMBL4589625 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3286929 | — | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4450839 | — | IC50 | = | 10300.0 | nM | 4.99 |
| CHEMBL4527667 | — | IC50 | = | 11300.0 | nM | 4.95 |
| CHEMBL4439169 | — | IC50 | = | 17100.0 | nM | 4.77 |
| CHEMBL4443518 | — | IC50 | = | 18300.0 | nM | 4.74 |
| CHEMBL4459864 | — | IC50 | = | 19300.0 | nM | 4.71 |
| CHEMBL4566147 | — | IC50 | = | 20300.0 | nM | 4.69 |
| CHEMBL4449262 | — | IC50 | = | 24100.0 | nM | 4.62 |
| CHEMBL4536719 | — | IC50 | = | 32600.0 | nM | 4.49 |
| CHEMBL4514611 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL4555739 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4532027 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL4589625 | — | IC50 | > | 50000.0 | nM | - |