Assay Detail
Binding
CHEMBL4413159
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to wild-type partial length human CDK11 (M1 to N360 residues) expressed in bacterial expression system by Kinomescan assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
CDK8 as a therapeutic target for cancers and recent developments in discovery of CDK8 inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 2 | 7.26 | 8.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4080906 | — | — | 1 | 8.00 |
| CHEMBL4226806 | — | — | 1 | 6.51 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4080906 | — | Kd | = | 10.0 | nM | 8.00 |
| CHEMBL4226806 | — | Kd | = | 310.0 | nM | 6.51 |