Assay Detail
Binding
CHEMBL4413207
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Inhibition of human HSP90 measured after 30 mins by fluorescence polarization assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.71 | 6.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476534 | — | — | 1 | 6.11 |
| CHEMBL4434775 | — | — | 1 | 5.57 |
| CHEMBL4434895 | — | — | 1 | 5.45 |
| CHEMBL3727577 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476534 | — | IC50 | = | 780.0 | nM | 6.11 |
| CHEMBL4434775 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL4434895 | — | IC50 | = | 3580.0 | nM | 5.45 |
| CHEMBL3727577 | — | IC50 | - | — | - |