Assay Detail
Binding
CHEMBL4413208
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human His-tagged PDK1 expressed in Escherichia coli by isothermal calorimetry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (CHEMBL4766) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.78 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4476534 | — | — | 1 | 6.06 |
| CHEMBL4434895 | — | — | 1 | 5.83 |
| CHEMBL4434775 | — | — | 1 | 5.46 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4476534 | — | Kd | = | 870.0 | nM | 6.06 |
| CHEMBL4434895 | — | Kd | = | 1490.0 | nM | 5.83 |
| CHEMBL4434775 | — | Kd | = | 3500.0 | nM | 5.46 |