Assay Detail
Binding
CHEMBL4413248
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of E2-activated human PDHK2
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial (CHEMBL3861) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
High-throughput screening of novel pyruvate dehydrogenase kinases inhibitors and biological evaluation of their in vitro and in vivo antiproliferative activity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 7.61 | 8.11 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579004 | — | — | 1 | 8.11 |
| CHEMBL1231132 | — | — | 1 | 7.10 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579004 | — | IC50 | = | 7.8 | nM | 8.11 |
| CHEMBL1231132 | — | IC50 | = | 80.0 | nM | 7.10 |