Assay Detail
Binding
CHEMBL4413402
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Inhibition of pig FLAG3-tagged DGKalpha expressed in African green monkey COS7 cells using 1,2-dioleoyl-sn-glycerol as substrate measured after 30 mins by ADP-Glo luminescence assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Sus scrofa |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Identification of a novel DGKα inhibitor for XLP-1 therapy by virtual screening.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 5.19 | 6.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4558937 | — | — | 1 | 6.22 |
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | — | 1 | 4.75 |
| CHEMBL259388 | — | — | 1 | 4.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4558937 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL261131 | DIACYLGLYCEROL KINASE INHIBITOR II | IC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL259388 | — | IC50 | = | 25000.0 | nM | 4.60 |