Assay Detail
Functional
CHEMBL4413409
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Antiproliferative activity against human RPMI8226 cells after 72 hrs by MTS assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | RPMI-8226 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Exploration of novel macrocyclic dipeptide N-benzyl amides as proteasome inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.43 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL451887 | CARFILZOMIB | 4.0 | 1 | 8.70 |
| CHEMBL4442152 | — | — | 1 | 7.82 |
| CHEMBL4542139 | — | — | 1 | 7.75 |
| CHEMBL2103884 | OPROZOMIB | 2.0 | 1 | 7.72 |
| CHEMBL4538960 | — | — | 1 | 7.57 |
| CHEMBL4456389 | — | — | 1 | 7.24 |
| CHEMBL4549674 | — | — | 1 | 7.23 |
| CHEMBL4438865 | — | — | 1 | 7.01 |
| CHEMBL4461175 | — | — | 1 | 6.76 |
| CHEMBL4588117 | — | — | 1 | 6.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL451887 | CARFILZOMIB | IC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4442152 | — | IC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4542139 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL2103884 | OPROZOMIB | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4538960 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL4456389 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4549674 | — | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL4438865 | — | IC50 | = | 97.0 | nM | 7.01 |
| CHEMBL4461175 | — | IC50 | = | 175.0 | nM | 6.76 |
| CHEMBL4588117 | — | IC50 | = | 301.0 | nM | 6.52 |