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Assay Detail

CHEMBL4413420

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiprotozoal activity against Leishmania donovani MHOM/ET/67/L82 axenic amastigote after 72 hrs by inverted microscopic analysis
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Leishmania donovani
Confidence 1 — Organism
Curated By Autocuration

Target

Leishmania donovani (CHEMBL367)
Type ORGANISM
Organism Leishmania donovani

Publication

Design, Synthesis, and Biological Evaluation of New 1-(Aryl-1 H-pyrrolyl)(phenyl)methyl-1 H-imidazole Derivatives as Antiprotozoal Agents.
Saccoliti F, Madia VN, Tudino V, De Leo A, Pescatori L, Messore A, De Vita D, Scipione L, Brun R, Kaiser M, Mäser P, Calvet CM, Jennings GK, Podust LM, Pepe G, Cirilli R, Faggi C, Di Marco A, Battista MR, Summa V, Costi R, Di Santo R.
J Med Chem (2019) 62 : 1330 -1347
PubMed 30615444 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 5.14 6.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL125 MILTEFOSINE 4.0 1 6.25
CHEMBL4535713 1 5.69
CHEMBL4551139 1 5.67
CHEMBL4439406 1 5.56
CHEMBL4468270 1 5.52
CHEMBL3084303 1 5.42
CHEMBL315874 1 5.42
CHEMBL4443900 1 5.32
CHEMBL4583115 1 5.31
CHEMBL4555752 1 5.30
CHEMBL420248 1 5.29
CHEMBL4452356 1 5.28
CHEMBL4438726 1 5.27
CHEMBL4566159 1 5.26
CHEMBL4571176 1 5.25
CHEMBL4569370 1 5.24
CHEMBL4526497 1 5.19
CHEMBL4516493 1 5.02
CHEMBL4445583 1 4.99
CHEMBL4441266 1 4.97
CHEMBL4521643 1 4.86
CHEMBL4452066 1 4.82
CHEMBL4453528 1 4.75
CHEMBL4528118 1 4.67
CHEMBL4571629 1 4.60
CHEMBL4557544 1 4.52
CHEMBL4456340 1 4.51
CHEMBL4441627 1 4.07

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL125 MILTEFOSINE IC50 = 560.0 nM 6.25
CHEMBL4535713 IC50 = 2040.0 nM 5.69
CHEMBL4551139 IC50 = 2160.0 nM 5.67
CHEMBL4439406 IC50 = 2780.0 nM 5.56
CHEMBL4468270 IC50 = 3010.0 nM 5.52
CHEMBL3084303 IC50 = 3770.0 nM 5.42
CHEMBL315874 IC50 = 3770.0 nM 5.42
CHEMBL4443900 IC50 = 4830.0 nM 5.32
CHEMBL4583115 IC50 = 4870.0 nM 5.31
CHEMBL4555752 IC50 = 5020.0 nM 5.30
CHEMBL420248 IC50 = 5120.0 nM 5.29
CHEMBL4452356 IC50 = 5220.0 nM 5.28
CHEMBL4438726 IC50 = 5340.0 nM 5.27
CHEMBL4566159 IC50 = 5510.0 nM 5.26
CHEMBL4571176 IC50 = 5640.0 nM 5.25
CHEMBL4569370 IC50 = 5700.0 nM 5.24
CHEMBL4526497 IC50 = 6410.0 nM 5.19
CHEMBL4516493 IC50 = 9540.0 nM 5.02
CHEMBL4445583 IC50 = 10150.0 nM 4.99
CHEMBL4441266 IC50 = 10750.0 nM 4.97
CHEMBL4521643 IC50 = 13890.0 nM 4.86
CHEMBL4452066 IC50 = 15010.0 nM 4.82
CHEMBL4453528 IC50 = 17720.0 nM 4.75
CHEMBL4528118 IC50 = 21280.0 nM 4.67
CHEMBL4571629 IC50 = 25160.0 nM 4.60
CHEMBL4557544 IC50 = 30380.0 nM 4.52
CHEMBL4456340 IC50 = 31070.0 nM 4.51
CHEMBL4441627 IC50 = 84430.0 nM 4.07