Assay Detail
Binding
CHEMBL4413545
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant N-terminal FLAG-tagged human mTOR (1362 to end residues) using ULight-4E-BP1 (Thr37/46) peptide as substrate after 1 hr by fluorescence assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 8.33 | 8.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4532398 | — | — | 1 | 8.92 |
| CHEMBL4437811 | — | — | 1 | 8.51 |
| CHEMBL4582850 | — | — | 1 | 8.47 |
| CHEMBL4552057 | — | — | 1 | 7.40 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4532398 | — | IC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4437811 | — | IC50 | = | 3.1 | nM | 8.51 |
| CHEMBL4582850 | — | IC50 | = | 3.4 | nM | 8.47 |
| CHEMBL4552057 | — | IC50 | = | 40.0 | nM | 7.40 |