Assay Detail
Functional
CHEMBL4413552
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Antiproliferative activity against human OCI-AML2 cells after 72 hrs by MTT assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | OCI-AML2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Novel Dual Histone Deacetylase and Mammalian Target of Rapamycin Target Inhibitors as a Promising Strategy for Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.72 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4437811 | — | — | 1 | 8.40 |
| CHEMBL4582850 | — | — | 1 | 8.07 |
| CHEMBL4532398 | — | — | 1 | 8.04 |
| CHEMBL4437152 | — | — | 1 | 8.01 |
| CHEMBL4466560 | — | — | 1 | 7.77 |
| CHEMBL4469377 | — | — | 1 | 7.74 |
| CHEMBL4535681 | — | — | 1 | 7.54 |
| CHEMBL4473569 | — | — | 1 | 7.48 |
| CHEMBL98 | VORINOSTAT | 4.0 | 1 | 6.41 |
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4437811 | — | IC50 | = | 3.97 | nM | 8.40 |
| CHEMBL4582850 | — | IC50 | = | 8.55 | nM | 8.07 |
| CHEMBL4532398 | — | IC50 | = | 9.01 | nM | 8.04 |
| CHEMBL4437152 | — | IC50 | = | 9.71 | nM | 8.01 |
| CHEMBL4466560 | — | IC50 | = | 16.95 | nM | 7.77 |
| CHEMBL4469377 | — | IC50 | = | 18.41 | nM | 7.74 |
| CHEMBL4535681 | — | IC50 | = | 28.96 | nM | 7.54 |
| CHEMBL4473569 | — | IC50 | = | 32.78 | nM | 7.48 |
| CHEMBL98 | VORINOSTAT | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL413 | SIROLIMUS | IC50 | > | 500.0 | nM | - |