Assay Detail
Binding
CHEMBL4413810
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inverse agonist activity at CMX-gal4-fused ERRgamma (unknown origin) transfected in human AD293 cells co-expressing CMV-beta galactosidase assessed as effect on beta-galactosidase activity after 24 hrs by luciferase reporter gene assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Potent, Selective, and Orally Bioavailable Estrogen-Related Receptor-γ Inverse Agonists To Restore the Sodium Iodide Symporter Function in Anaplastic Thyroid Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 10 | 7.54 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4436391 | — | — | 1 | 8.22 |
| CHEMBL4437929 | — | — | 1 | 7.75 |
| CHEMBL4580171 | — | — | 1 | 7.75 |
| CHEMBL4579002 | — | — | 1 | 7.75 |
| CHEMBL4451327 | — | — | 1 | 7.70 |
| CHEMBL4443694 | — | — | 1 | 7.19 |
| CHEMBL4541589 | — | — | 1 | 7.19 |
| CHEMBL4472718 | — | — | 1 | 7.16 |
| CHEMBL3932162 | — | — | 1 | 7.11 |
| CHEMBL4585424 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4436391 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4437929 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4580171 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4579002 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4451327 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4443694 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL4541589 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL4472718 | — | IC50 | = | 69.0 | nM | 7.16 |
| CHEMBL3932162 | — | IC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4585424 | — | IC50 | - | — | - |