Assay Detail
Binding
CHEMBL4414026
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ERG
11
Total Activities
11
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
6-Amino-3-methylpyrimidinones as Potent, Selective, and Orally Efficacious SHP2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 5.21 | 5.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4546378 | — | — | 1 | 5.40 |
| CHEMBL4533113 | — | — | 1 | 5.22 |
| CHEMBL4578698 | — | — | 1 | 5.01 |
| CHEMBL4476848 | — | — | 1 | - |
| CHEMBL4442335 | — | — | 1 | - |
| CHEMBL4531137 | — | — | 1 | - |
| CHEMBL4447768 | — | — | 1 | - |
| CHEMBL4468062 | — | — | 1 | - |
| CHEMBL4546245 | — | — | 1 | - |
| CHEMBL4581388 | — | — | 1 | - |
| CHEMBL4537504 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4546378 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL4533113 | — | IC50 | = | 6000.0 | nM | 5.22 |
| CHEMBL4578698 | — | IC50 | = | 9800.0 | nM | 5.01 |
| CHEMBL4476848 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4442335 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4531137 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4447768 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4468062 | — | IC50 | - | — | - | |
| CHEMBL4546245 | — | IC50 | - | — | - | |
| CHEMBL4581388 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4537504 | — | IC50 | > | 30000.0 | nM | - |