Assay Detail
Binding
CHEMBL4414124
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Inhibition of human ERG by Q-patch assay
15
Total Activities
15
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Voltage-gated inwardly rectifying potassium channel KCNH2 (CHEMBL240) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Optimization of Fused Bicyclic Allosteric SHP2 Inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 15 | 6.37 | 8.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4475043 | — | — | 1 | 8.40 |
| CHEMBL4475081 | — | — | 1 | 8.15 |
| CHEMBL4469071 | — | — | 1 | 6.70 |
| CHEMBL4437876 | — | — | 1 | 6.60 |
| CHEMBL4455446 | — | — | 1 | 6.54 |
| CHEMBL4459445 | — | — | 1 | 6.03 |
| CHEMBL4539145 | — | — | 1 | 6.01 |
| CHEMBL4461938 | — | — | 1 | 5.92 |
| CHEMBL4450282 | — | — | 1 | 5.72 |
| CHEMBL4471006 | — | — | 1 | 5.18 |
| CHEMBL4439006 | — | — | 1 | 4.77 |
| CHEMBL4452417 | — | — | 1 | - |
| CHEMBL4539178 | — | — | 1 | - |
| CHEMBL4436233 | — | — | 1 | - |
| CHEMBL4570587 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4475043 | — | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4475081 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4469071 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL4437876 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4455446 | — | IC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4459445 | — | IC50 | = | 930.0 | nM | 6.03 |
| CHEMBL4539145 | — | IC50 | = | 980.0 | nM | 6.01 |
| CHEMBL4461938 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4450282 | — | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL4471006 | — | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4439006 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL4452417 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4539178 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4436233 | — | IC50 | > | 30000.0 | nM | - |
| CHEMBL4570587 | — | IC50 | > | 30000.0 | nM | - |