Assay Detail
Binding
CHEMBL4414348
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant RXRalpha (unknown origin) by isothermal titration calorimetry
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Tuning Nuclear Receptor Selectivity of Wy14,643 towards Selective Retinoid X Receptor Modulation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 6 | 6.42 | 7.02 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4558880 | — | — | 1 | 7.02 |
| CHEMBL1023 | BEXAROTENE | 4.0 | 1 | 6.68 |
| CHEMBL4575123 | — | — | 1 | 6.46 |
| CHEMBL4518775 | — | — | 1 | 6.06 |
| CHEMBL295416 | PIRINIXIC ACID | 2.0 | 1 | 5.89 |
| CHEMBL459972 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4558880 | — | Kd | = | 95.0 | nM | 7.02 |
| CHEMBL1023 | BEXAROTENE | Kd | = | 210.0 | nM | 6.68 |
| CHEMBL4575123 | — | Kd | = | 350.0 | nM | 6.46 |
| CHEMBL4518775 | — | Kd | = | 880.0 | nM | 6.06 |
| CHEMBL295416 | PIRINIXIC ACID | Kd | = | 1280.0 | nM | 5.89 |
| CHEMBL459972 | — | Kd | - | — | - |