Assay Detail
Functional
CHEMBL4414686
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Antiproliferative activity against human MM1S cells incubated for 72 hrs by MTT assay
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MM1.S |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Dihydropyrimidine-2-thiones as Eg5 inhibitors and L-type calcium channel blockers: potential antitumour dual agents.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 9 | 4.38 | 5.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL236789 | MONASTROL | — | 1 | 5.06 |
| CHEMBL193 | NIFEDIPINE | 4.0 | 1 | 4.24 |
| CHEMBL4580791 | — | — | 1 | 4.20 |
| CHEMBL86889 | — | — | 1 | 4.01 |
| CHEMBL4458540 | — | — | 1 | - |
| CHEMBL2013079 | — | — | 1 | - |
| CHEMBL4585154 | — | — | 1 | - |
| CHEMBL4203316 | — | — | 1 | - |
| CHEMBL4520875 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL236789 | MONASTROL | IC50 | = | 8700.0 | nM | 5.06 |
| CHEMBL193 | NIFEDIPINE | IC50 | = | 57900.0 | nM | 4.24 |
| CHEMBL4580791 | — | IC50 | = | 63100.0 | nM | 4.20 |
| CHEMBL86889 | — | IC50 | = | 96500.0 | nM | 4.01 |
| CHEMBL4458540 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL2013079 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4585154 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4203316 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4520875 | — | IC50 | > | 100000.0 | nM | - |