Assay Detail
Functional
CHEMBL4414909
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Antiproliferative activity against human Rec1 cells after 6 days by Celltiter-glo luminescent cell viability assay
11
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | Rec1 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of Zanubrutinib (BGB-3111), a Novel, Potent, and Selective Covalent Inhibitor of Bruton's Tyrosine Kinase.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 11 | 9.07 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3965549 | — | — | 3 | 9.70 |
| CHEMBL3936761 | ZANUBRUTINIB | 4.0 | 1 | 9.44 |
| CHEMBL3977729 | — | — | 3 | 8.89 |
| CHEMBL3944698 | — | — | 1 | 8.89 |
| CHEMBL3973435 | — | — | 1 | - |
| CHEMBL4107402 | — | — | 1 | - |
| CHEMBL3916800 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3965549 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3965549 | — | IC50 | = | 0.2 | nM | 9.70 |
| CHEMBL3936761 | ZANUBRUTINIB | IC50 | = | 0.36 | nM | 9.44 |
| CHEMBL3977729 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3944698 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL3977729 | — | IC50 | = | 15.5 | nM | 7.81 |
| CHEMBL3973435 | — | IC50 | - | — | - | |
| CHEMBL4107402 | — | IC50 | - | — | - | |
| CHEMBL3965549 | — | IC50 | - | — | - | |
| CHEMBL3977729 | — | IC50 | - | — | - | |
| CHEMBL3916800 | — | IC50 | - | — | - |