Assay Detail
Functional
CHEMBL4415073
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Dengue virus 3 D3MY05-34640 infected in human HuH7 replicon cells expressing Renilla luciferase and neomycin-resistance genes assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter replicon-based assay
60
Total Activities
60
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5-<i>b</i>]pyridine-7,3'-indoline]-2',5(3<i>H</i>)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 60 | 7.50 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4548394 | — | — | 1 | 9.00 |
| CHEMBL4538323 | — | — | 1 | 8.70 |
| CHEMBL4515898 | — | — | 1 | 8.52 |
| CHEMBL4576872 | — | — | 1 | 8.52 |
| CHEMBL4449100 | — | — | 1 | 8.40 |
| CHEMBL4459642 | — | — | 1 | 8.30 |
| CHEMBL4447223 | — | — | 1 | 8.30 |
| CHEMBL4437627 | — | — | 1 | 8.30 |
| CHEMBL4459948 | — | — | 1 | 8.22 |
| CHEMBL4483405 | — | — | 1 | 8.22 |
| CHEMBL4475296 | — | — | 1 | 8.22 |
| CHEMBL4455078 | — | — | 1 | 8.15 |
| CHEMBL4536890 | — | — | 1 | 8.05 |
| CHEMBL4465077 | — | — | 1 | 8.05 |
| CHEMBL4458661 | — | — | 1 | 8.05 |
| CHEMBL4572212 | — | — | 1 | 8.00 |
| CHEMBL4586370 | — | — | 1 | 8.00 |
| CHEMBL4453707 | — | — | 1 | 8.00 |
| CHEMBL4538647 | — | — | 1 | 7.96 |
| CHEMBL4471004 | — | — | 1 | 7.96 |
| CHEMBL4470346 | — | — | 1 | 7.92 |
| CHEMBL4540549 | — | — | 1 | 7.78 |
| CHEMBL4521110 | — | — | 1 | 7.77 |
| CHEMBL4571778 | — | — | 1 | 7.77 |
| CHEMBL4470440 | — | — | 1 | 7.75 |
| CHEMBL4459375 | — | — | 1 | 7.75 |
| CHEMBL4471937 | — | — | 1 | 7.72 |
| CHEMBL4534709 | — | — | 1 | 7.72 |
| CHEMBL4579860 | — | — | 1 | 7.70 |
| CHEMBL4451009 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4548394 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4538323 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4576872 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4515898 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4449100 | — | EC50 | = | 4.0 | nM | 8.40 |
| CHEMBL4459642 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4447223 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4437627 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4459948 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4475296 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4483405 | — | EC50 | = | 6.0 | nM | 8.22 |
| CHEMBL4455078 | — | EC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4465077 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4458661 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4536890 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL4572212 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4453707 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4586370 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4538647 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4471004 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4470346 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4540549 | — | EC50 | = | 16.7 | nM | 7.78 |
| CHEMBL4521110 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4571778 | — | EC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4459375 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4470440 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4471937 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4534709 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4579860 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4451009 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4475139 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4575020 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4436766 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4452845 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4467064 | — | EC50 | = | 30.0 | nM | 7.52 |
| CHEMBL4446551 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL4472422 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4513651 | — | EC50 | = | 42.0 | nM | 7.38 |
| CHEMBL4470681 | — | EC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4565921 | — | EC50 | = | 51.0 | nM | 7.29 |
| CHEMBL4574618 | — | EC50 | = | 66.0 | nM | 7.18 |
| CHEMBL4521186 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4554332 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4473559 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4555033 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL4434650 | — | EC50 | = | 87.0 | nM | 7.06 |
| CHEMBL4593413 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL4548448 | — | EC50 | = | 140.0 | nM | 6.85 |
| CHEMBL4569686 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4476758 | — | EC50 | = | 200.0 | nM | 6.70 |