Assay Detail
Functional
CHEMBL4415074
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against Dengue virus 2 NGC infected in human HuH7 replicon cells expressing Renilla luciferase and neomycin-resistance genes assessed as reduction in viral replication incubated for 48 hrs by luciferase reporter replicon-based assay
63
Total Activities
63
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | dengue virus type 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, Synthesis, and Biological Evaluation of Substituted 4,6-Dihydrospiro[[1,2,3]triazolo[4,5-<i>b</i>]pyridine-7,3'-indoline]-2',5(3<i>H</i>)-dione Analogues as Potent NS4B Inhibitors for the Treatment of Dengue Virus Infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 63 | 6.79 | 7.72 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4449100 | — | — | 1 | 7.72 |
| CHEMBL4515898 | — | — | 1 | 7.70 |
| CHEMBL4458661 | — | — | 1 | 7.64 |
| CHEMBL4483405 | — | — | 1 | 7.62 |
| CHEMBL4538323 | — | — | 1 | 7.60 |
| CHEMBL4548394 | — | — | 1 | 7.60 |
| CHEMBL4575020 | — | — | 1 | 7.54 |
| CHEMBL4572212 | — | — | 1 | 7.43 |
| CHEMBL4536890 | — | — | 1 | 7.42 |
| CHEMBL4475296 | — | — | 1 | 7.42 |
| CHEMBL4437627 | — | — | 1 | 7.42 |
| CHEMBL4453707 | — | — | 1 | 7.41 |
| CHEMBL4465077 | — | — | 1 | 7.40 |
| CHEMBL4540549 | — | — | 1 | 7.38 |
| CHEMBL4451009 | — | — | 1 | 7.20 |
| CHEMBL4455078 | — | — | 1 | 7.17 |
| CHEMBL4576872 | — | — | 1 | 7.16 |
| CHEMBL4586370 | — | — | 1 | 7.15 |
| CHEMBL4452845 | — | — | 1 | 7.14 |
| CHEMBL4471937 | — | — | 1 | 7.14 |
| CHEMBL4447223 | — | — | 1 | 7.13 |
| CHEMBL4459642 | — | — | 1 | 7.12 |
| CHEMBL4470440 | — | — | 1 | 7.12 |
| CHEMBL4571778 | — | — | 1 | 7.12 |
| CHEMBL4538647 | — | — | 1 | 7.11 |
| CHEMBL4459375 | — | — | 1 | 7.11 |
| CHEMBL4459948 | — | — | 1 | 7.11 |
| CHEMBL4534709 | — | — | 1 | 7.04 |
| CHEMBL4521110 | — | — | 1 | 6.96 |
| CHEMBL4436766 | — | — | 1 | 6.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4449100 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL4515898 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4458661 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL4483405 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL4538323 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4548394 | — | EC50 | = | 25.0 | nM | 7.60 |
| CHEMBL4575020 | — | EC50 | = | 29.0 | nM | 7.54 |
| CHEMBL4572212 | — | EC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4536890 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4475296 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4437627 | — | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL4453707 | — | EC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4465077 | — | EC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4540549 | — | EC50 | = | 41.4 | nM | 7.38 |
| CHEMBL4451009 | — | EC50 | = | 63.0 | nM | 7.20 |
| CHEMBL4455078 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL4576872 | — | EC50 | = | 69.0 | nM | 7.16 |
| CHEMBL4586370 | — | EC50 | = | 71.0 | nM | 7.15 |
| CHEMBL4452845 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL4471937 | — | EC50 | = | 73.0 | nM | 7.14 |
| CHEMBL4447223 | — | EC50 | = | 74.0 | nM | 7.13 |
| CHEMBL4459642 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL4470440 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4571778 | — | EC50 | = | 75.0 | nM | 7.12 |
| CHEMBL4459948 | — | EC50 | = | 78.0 | nM | 7.11 |
| CHEMBL4459375 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4538647 | — | EC50 | = | 77.0 | nM | 7.11 |
| CHEMBL4534709 | — | EC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4521110 | — | EC50 | = | 110.0 | nM | 6.96 |
| CHEMBL4436766 | — | EC50 | = | 120.0 | nM | 6.92 |
| CHEMBL4470346 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4471004 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4579860 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4475139 | — | EC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4446551 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4470681 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4472422 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4554332 | — | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL4521186 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4565921 | — | EC50 | = | 290.0 | nM | 6.54 |
| CHEMBL4467064 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4473559 | — | EC50 | = | 350.0 | nM | 6.46 |
| CHEMBL4513651 | — | EC50 | = | 490.0 | nM | 6.31 |
| CHEMBL4569686 | — | EC50 | = | 600.0 | nM | 6.22 |
| CHEMBL4548448 | — | EC50 | = | 810.0 | nM | 6.09 |
| CHEMBL4434650 | — | EC50 | = | 830.0 | nM | 6.08 |
| CHEMBL4568250 | — | EC50 | = | 860.0 | nM | 6.07 |
| CHEMBL4555033 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL4574618 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL4532280 | — | EC50 | = | 2400.0 | nM | 5.62 |