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Assay Detail

CHEMBL4415150

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of TSPO (unknown origin)
12
Total Activities
11
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Translocator protein (CHEMBL5742)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Imidazopyridine-based selective and multifunctional ligands of biological targets associated with psychiatric and neurodegenerative diseases.
Vanda D, Zajdel P, Soural M.
Eur J Med Chem (2019) 181 : 111569 -111569
PubMed 31404862 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 9 8.85 9.82
IC50 3 8.23 8.67

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL520465 1 9.82
CHEMBL432608 ALPDEM 1 9.39
CHEMBL54349 ALPIDEM 4.0 2 9.30
CHEMBL509917 1 9.27
CHEMBL483596 1 9.07
CHEMBL521186 1 9.05
CHEMBL339816 1 8.80
CHEMBL4456416 1 8.67
CHEMBL97269 1 8.41
CHEMBL106237 1 7.93
CHEMBL3287610 1 6.53

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL520465 Ki = 0.15 nM 9.82
CHEMBL432608 ALPDEM Ki = 0.41 nM 9.39
CHEMBL54349 ALPIDEM Ki = 0.5 nM 9.30
CHEMBL509917 Ki = 0.537 nM 9.27
CHEMBL483596 Ki = 0.86 nM 9.07
CHEMBL521186 Ki = 0.882 nM 9.05
CHEMBL339816 Ki = 1.6 nM 8.80
CHEMBL4456416 IC50 = 2.13 nM 8.67
CHEMBL97269 Ki = 3.9 nM 8.41
CHEMBL54349 ALPIDEM IC50 = 7.9 nM 8.10
CHEMBL106237 IC50 = 11.8 nM 7.93
CHEMBL3287610 Ki = 293.0 nM 6.53