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Assay Detail

CHEMBL4415257

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of electric eel AChE incubated for 15 mins by Ellman's method
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Electrophorus electricus
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Acetylcholinesterase (CHEMBL4078)
Type SINGLE PROTEIN
Organism Electrophorus electricus

Publication

Cholinesterase Inhibitory Arisugacins L-Q from a <i>Penicillium</i> sp. Isolate Obtained through a Citizen Science Initiative and Their Activities in a Phenotype-Based Zebrafish Assay.
Dai W, Sandoval IT, Cai S, Smith KA, Delacruz RGC, Boyd KA, Mills JJ, Jones DA, Cichewicz RH.
J Nat Prod (2019) 82 : 2627 -2637
PubMed 31433188 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.94 8.11

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL94 PHYSOSTIGMINE 3.0 1 8.11
CHEMBL4440372 1 6.72
CHEMBL3632852 1 5.85
CHEMBL4471625 1 5.41
CHEMBL4575080 1 5.34
CHEMBL4514571 1 4.18
CHEMBL530115 GUTHION 1 -
CHEMBL3632853 1 -
CHEMBL4461886 1 -
CHEMBL4553044 1 -
CHEMBL4471396 1 -
CHEMBL494887 TETRAISOPROPYL PYROPHOSPHORAMIDE 1 -
CHEMBL3632855 1 -
CHEMBL3632856 1 -
CHEMBL4567427 1 -
CHEMBL4533666 1 -
CHEMBL4446983 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL94 PHYSOSTIGMINE IC50 = 7.8 nM 8.11
CHEMBL4440372 IC50 = 191.0 nM 6.72
CHEMBL3632852 IC50 = 1400.0 nM 5.85
CHEMBL4471625 IC50 = 3900.0 nM 5.41
CHEMBL4575080 IC50 = 4600.0 nM 5.34
CHEMBL4514571 IC50 = 66000.0 nM 4.18
CHEMBL530115 GUTHION IC50 - -
CHEMBL3632853 IC50 - -
CHEMBL4461886 IC50 - -
CHEMBL4553044 IC50 > 100000.0 nM -
CHEMBL4471396 IC50 > 100000.0 nM -
CHEMBL494887 TETRAISOPROPYL PYROPHOSPHORAMIDE IC50 > 100000.0 nM -
CHEMBL3632855 IC50 - -
CHEMBL3632856 IC50 > 100000.0 nM -
CHEMBL4567427 IC50 - -
CHEMBL4533666 IC50 > 100000.0 nM -
CHEMBL4446983 IC50 - -