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Assay Detail

CHEMBL4415261

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Binding
Binding affinity to hexa-His-tagged human soluble epoxide hydrolase N-terminal phosphatase domain expressed in Escherichia coli BL21(DE3) by ITC assay
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Discovery of the First in Vivo Active Inhibitors of the Soluble Epoxide Hydrolase Phosphatase Domain.
Kramer JS, Woltersdorf S, Duflot T, Hiesinger K, Lillich FF, Knöll F, Wittmann SK, Klingler FM, Brunst S, Chaikuad A, Morisseau C, Hammock BD, Buccellati C, Sala A, Rovati GE, Leuillier M, Fraineau S, Rondeaux J, Hernandez-Olmos V, Heering J, Merk D, Pogoryelov D, Steinhilber D, Knapp S, Bellien J, Proschak E.
J Med Chem (2019) 62 : 8443 -8460
PubMed 31436984 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 1 6.52 6.52

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4445524 1 6.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4445524 Kd = 300.0 nM 6.52