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Assay Detail

CHEMBL4415482

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Functional
Antiproliferative activity against human MM1S cells after 72 hrs by CCK8 or SRB assay
28
Total Activities
28
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MM1.S
Confidence 1 — Organism
Curated By Autocuration

Target

MM1.S (CHEMBL4296471)
Type CELL-LINE
Organism Homo sapiens

Publication

Structure-Based Discovery and Development of a Series of Potent and Selective Bromodomain and Extra-Terminal Protein Inhibitors.
Hu J, Tian CQ, Damaneh MS, Li Y, Cao D, Lv K, Yu T, Meng T, Chen D, Wang X, Chen L, Li J, Song SS, Huan XJ, Qin L, Shen J, Wang YQ, Miao ZH, Xiong B.
J Med Chem (2019) 62 : 8642 -8663
PubMed 31490070 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 28 7.53 8.64

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4451357 1 8.64
CHEMBL4578490 1 8.48
CHEMBL4463165 1 8.41
CHEMBL3581647 BIRABRESIB 2.0 1 8.20
CHEMBL4454674 1 8.19
CHEMBL4585487 1 8.17
CHEMBL4553774 1 8.10
CHEMBL4449874 1 8.10
CHEMBL4556261 1 8.10
CHEMBL4583525 1 8.00
CHEMBL4550548 1 7.89
CHEMBL4577433 1 7.79
CHEMBL4587000 1 7.75
CHEMBL4561468 1 7.60
CHEMBL4573400 1 7.58
CHEMBL1957266 1 7.53
CHEMBL4582401 1 7.36
CHEMBL4585185 1 7.32
CHEMBL4441607 1 7.31
CHEMBL4452579 1 7.22
CHEMBL4445973 1 7.06
CHEMBL4518804 1 6.90
CHEMBL4445310 1 6.32
CHEMBL4584184 1 6.31
CHEMBL4537909 1 5.91
CHEMBL4470399 1 5.62
CHEMBL4465676 1 -
CHEMBL4572470 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4451357 IC50 = 2.3 nM 8.64
CHEMBL4578490 IC50 = 3.3 nM 8.48
CHEMBL4463165 IC50 = 3.9 nM 8.41
CHEMBL3581647 BIRABRESIB IC50 = 6.3 nM 8.20
CHEMBL4454674 IC50 = 6.4 nM 8.19
CHEMBL4585487 IC50 = 6.7 nM 8.17
CHEMBL4553774 IC50 = 7.9 nM 8.10
CHEMBL4449874 IC50 = 8.0 nM 8.10
CHEMBL4556261 IC50 = 8.0 nM 8.10
CHEMBL4583525 IC50 = 10.1 nM 8.00
CHEMBL4550548 IC50 = 13.0 nM 7.89
CHEMBL4577433 IC50 = 16.2 nM 7.79
CHEMBL4587000 IC50 = 17.8 nM 7.75
CHEMBL4561468 IC50 = 25.1 nM 7.60
CHEMBL4573400 IC50 = 26.1 nM 7.58
CHEMBL1957266 IC50 = 29.8 nM 7.53
CHEMBL4582401 IC50 = 43.5 nM 7.36
CHEMBL4585185 IC50 = 47.7 nM 7.32
CHEMBL4441607 IC50 = 48.5 nM 7.31
CHEMBL4452579 IC50 = 60.1 nM 7.22
CHEMBL4445973 IC50 = 87.5 nM 7.06
CHEMBL4518804 IC50 = 125.0 nM 6.90
CHEMBL4445310 IC50 = 484.6 nM 6.32
CHEMBL4584184 IC50 = 484.8 nM 6.31
CHEMBL4537909 IC50 = 1228.7 nM 5.91
CHEMBL4470399 IC50 = 2403.0 nM 5.62
CHEMBL4465676 IC50 - -
CHEMBL4572470 IC50 - -