Assay Detail

CHEMBL4415753

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Functional

Antitumor activity against human MCF7 cells by SRB assay

ChEMBL ↗

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Target

MCF7 (CHEMBL387) ↗

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Primary target MCF7

CHEMBL387

Anchored from Assay target.

Protein identity MCF7

Disease frame Disease evidence pending

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Review focus Open DB context pending

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Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Functional
Organism	Homo sapiens
Cell Type	MCF7
Confidence	1 — Organism
Curated By	Autocuration

Target

MCF7 (CHEMBL387) ↗

Type	CELL-LINE
Organism	Homo sapiens

Publication

Design and synthesis of pentacyclic triterpene conjugates and their use in medicinal research.

Hodon J, Borkova L, Pokorny J, Kazakova A, Urban M.
Eur J Med Chem (2019) 182 : 111653 -111653
PubMed 31499360 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	2	6.17	6.48

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL269277	BETULINIC ACID	1.0	1	6.48
CHEMBL4438846	—	—	1	5.85

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL269277	BETULINIC ACID	IC50	=	330.0	nM	6.48
CHEMBL4438846	—	IC50	=	1400.0	nM	5.85