Assay Detail
Binding
CHEMBL4415819
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Inhibition of full-length human IDO1 expressed in Escherichia coli Rosetta (DE3) using L-Trp substrate by HPLC analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.66 | 7.28 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2148074 | — | — | 1 | 7.28 |
| CHEMBL584991 | — | — | 1 | 6.50 |
| CHEMBL14145 | — | — | 1 | 4.70 |
| CHEMBL4443463 | — | — | 1 | 4.16 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2148074 | — | IC50 | = | 53.0 | nM | 7.28 |
| CHEMBL584991 | — | IC50 | = | 320.0 | nM | 6.50 |
| CHEMBL14145 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL4443463 | — | IC50 | = | 70000.0 | nM | 4.16 |