Assay Detail
Binding
CHEMBL4415955
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antagonist activity at human P2X4R transfected in 1321N1 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by Fura-2AM assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 5.96 | 6.38 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2180160 | — | — | 1 | 6.38 |
| CHEMBL1532400 | — | — | 1 | 6.26 |
| CHEMBL2180179 | — | — | 1 | 5.24 |
| CHEMBL562308 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2180160 | — | IC50 | = | 420.0 | nM | 6.38 |
| CHEMBL1532400 | — | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL2180179 | — | IC50 | = | 5700.0 | nM | 5.24 |
| CHEMBL562308 | — | IC50 | - | — | - |