Assay Detail
Binding
CHEMBL4415957
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Antagonist activity at human P2X7R transfected in HEK293 cells assessed as inhibition of ATP-mediated calcium influx measured after 10 mins by YOPRO-1 dye uptake assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Development of High-Throughput Fluorescent-Based Screens to Accelerate Discovery of P2X Inhibitors from Animal Venoms.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.04 | 4.04 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL562308 | — | — | 1 | 4.04 |
| CHEMBL1532400 | — | — | 1 | - |
| CHEMBL2180160 | — | — | 1 | - |
| CHEMBL2180179 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL562308 | — | IC50 | = | 92000.0 | nM | 4.04 |
| CHEMBL1532400 | — | IC50 | - | — | - | |
| CHEMBL2180160 | — | IC50 | - | — | - | |
| CHEMBL2180179 | — | IC50 | - | — | - |