Assay Detail
Binding
CHEMBL4416028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of N-terminal His-tagged human XIAP-BIR3 (253 to 347 residues) expressed in Escherichia coli BL21-Gold(DE3) pLysS incubated for 2 hrs after 6 hrs pre-incubation with enzyme by biotinylated AVPI peptide based DELFIA
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.63 | 7.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4552412 | — | — | 1 | 7.96 |
| CHEMBL4581366 | — | — | 1 | 7.92 |
| CHEMBL4437401 | — | — | 1 | 7.55 |
| CHEMBL2431768 | LCL-161 | 2.0 | 1 | 7.40 |
| CHEMBL2158051 | XEVINAPANT | 3.0 | 1 | 7.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4552412 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4581366 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL4437401 | — | IC50 | = | 28.0 | nM | 7.55 |
| CHEMBL2431768 | LCL-161 | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL2158051 | XEVINAPANT | IC50 | = | 47.8 | nM | 7.32 |