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Assay Detail

CHEMBL4416057

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against P-gp overexpressing human KBVIN cells assessed as reduction in cell viability after 72 hrs by SRB assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Confidence 0 — Uncurated / Unknown
Curated By Autocuration

Target

Unchecked (CHEMBL612545)
Type UNCHECKED

Publication

Prenylated Acetophloroglucinol Dimers from Acronychia trifoliolata: Structure Elucidation and Total Synthesis.
Miyake K, Morita C, Suzuki A, Matsushita N, Saito Y, Goto M, Newman DJ, O'Keefe BR, Lee KH, Nakagawa-Goto K.
J Nat Prod (2019) 82 : 2852 -2858
PubMed 31550158 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 12 5.27 5.37

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4101532 1 5.37
CHEMBL488313 1 5.36
CHEMBL428647 PACLITAXEL 4.0 1 5.34
CHEMBL4559378 1 5.30
CHEMBL4572258 1 5.29
CHEMBL4458801 1 5.26
CHEMBL2088323 ACROVESTENOL 1 5.19
CHEMBL4543046 1 5.08
CHEMBL1984096 1 -
CHEMBL4469278 1 -
CHEMBL4077368 1 -
CHEMBL4078358 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4101532 IC50 = 4300.0 nM 5.37
CHEMBL488313 IC50 = 4400.0 nM 5.36
CHEMBL428647 PACLITAXEL IC50 = 4531.0 nM 5.34
CHEMBL4559378 IC50 = 5000.0 nM 5.30
CHEMBL4572258 IC50 = 5100.0 nM 5.29
CHEMBL4458801 IC50 = 5500.0 nM 5.26
CHEMBL2088323 ACROVESTENOL IC50 = 6500.0 nM 5.19
CHEMBL4543046 IC50 = 8400.0 nM 5.08
CHEMBL1984096 IC50 > 10000.0 nM -
CHEMBL4469278 IC50 > 10000.0 nM -
CHEMBL4077368 IC50 > 10000.0 nM -
CHEMBL4078358 IC50 > 10000.0 nM -