Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4416180

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiplasmodial activity against asexual form of Plasmodium falciparum NF54 assessed as reduction in female gametocytes activation preincubated for 48 hrs followed by gametocytes activation and measured after 24 hrs by fluorescence based automated inverted microscopic analysis
38
Total Activities
38
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Plasmodium falciparum
Confidence 1 — Organism
Curated By Autocuration

Target

Plasmodium falciparum (CHEMBL364)
Type ORGANISM
Organism Plasmodium falciparum

Publication

Development of Chemical Entities Endowed with Potent Fast-Killing Properties against <i>Plasmodium falciparum</i> Malaria Parasites.
Matralis AN, Malik A, Penzo M, Moreno I, Almela MJ, Camino I, Crespo B, Saadeddin A, Ghidelli-Disse S, Rueda L, Calderon F, Osborne SA, Drewes G, Böesche M, Fernández-Álvaro E, Martin Hernando JI, Baker DA.
J Med Chem (2019) 62 : 9217 -9235
PubMed 31566384 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
EC50 38 6.18 6.72

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4459320 1 6.72
CHEMBL4531058 1 6.52
CHEMBL4566588 1 6.42
CHEMBL4591417 1 6.40
CHEMBL4451783 1 6.39
CHEMBL4473609 1 6.33
CHEMBL4288103 1 6.32
CHEMBL4455587 1 6.11
CHEMBL4531226 1 5.97
CHEMBL4459919 1 5.88
CHEMBL4436765 1 4.97
CHEMBL4572858 1 -
CHEMBL4469667 1 -
CHEMBL4583048 1 -
CHEMBL4446024 1 -
CHEMBL4446015 1 -
CHEMBL4546641 1 -
CHEMBL4572065 1 -
CHEMBL361497 ARTESUNATE 4.0 1 -
CHEMBL4516715 1 -
CHEMBL4586918 1 -
CHEMBL4548154 1 -
CHEMBL4461276 1 -
CHEMBL4449947 1 -
CHEMBL4585479 1 -
CHEMBL4519443 1 -
CHEMBL4526454 1 -
CHEMBL4513311 1 -
CHEMBL36 PYRIMETHAMINE 4.0 1 -
CHEMBL4438004 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4459320 EC50 = 190.0 nM 6.72
CHEMBL4531058 EC50 = 300.0 nM 6.52
CHEMBL4566588 EC50 = 380.0 nM 6.42
CHEMBL4591417 EC50 = 400.0 nM 6.40
CHEMBL4451783 EC50 = 410.0 nM 6.39
CHEMBL4473609 EC50 = 470.0 nM 6.33
CHEMBL4288103 EC50 = 480.0 nM 6.32
CHEMBL4455587 EC50 = 780.0 nM 6.11
CHEMBL4531226 EC50 = 1070.0 nM 5.97
CHEMBL4459919 EC50 = 1310.0 nM 5.88
CHEMBL4436765 EC50 = 10600.0 nM 4.97
CHEMBL4446015 EC50 - -
CHEMBL4464676 EC50 - -
CHEMBL4446024 EC50 - -
CHEMBL4583048 EC50 - -
CHEMBL4469667 EC50 - -
CHEMBL4572858 EC50 - -
CHEMBL4593717 EC50 - -
CHEMBL4444451 EC50 - -
CHEMBL4532321 EC50 - -
CHEMBL4460574 EC50 - -
CHEMBL4567664 EC50 - -
CHEMBL4462111 EC50 - -
CHEMBL4585607 EC50 - -
CHEMBL4546641 EC50 - -
CHEMBL4572065 EC50 - -
CHEMBL361497 ARTESUNATE EC50 > 10000.0 nM -
CHEMBL4516715 EC50 - -
CHEMBL4586918 EC50 - -
CHEMBL4548154 EC50 - -
CHEMBL4461276 EC50 - -
CHEMBL4449947 EC50 - -
CHEMBL4585479 EC50 - -
CHEMBL4519443 EC50 - -
CHEMBL4526454 EC50 - -
CHEMBL4513311 EC50 - -
CHEMBL36 PYRIMETHAMINE EC50 > 10000.0 nM -
CHEMBL4438004 EC50 - -