Assay Detail
Functional
CHEMBL4416191
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Antiplasmodial activity against Plasmodium falciparum 3D7A asexual erythrocytic stage assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition and measured after 24 hrs by microbeta scintillation counting method
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Development of Chemical Entities Endowed with Potent Fast-Killing Properties against <i>Plasmodium falciparum</i> Malaria Parasites.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 6.37 | 6.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4591417 | — | — | 1 | 6.89 |
| CHEMBL4473609 | — | — | 1 | 6.72 |
| CHEMBL4572065 | — | — | 1 | 6.36 |
| CHEMBL4286841 | — | — | 1 | 5.99 |
| CHEMBL4446015 | — | — | 1 | 5.87 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4591417 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL4473609 | — | EC50 | = | 190.0 | nM | 6.72 |
| CHEMBL4572065 | — | EC50 | = | 440.0 | nM | 6.36 |
| CHEMBL4286841 | — | EC50 | = | 1020.0 | nM | 5.99 |
| CHEMBL4446015 | — | EC50 | = | 1360.0 | nM | 5.87 |