Assay Detail
Binding
CHEMBL4416290
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Inhibition of bacterial Beta-lactamase TEM-1 M182T mutant pre-incubated for 5 mins before addition of chromogenic beta-lactamase substrate CENTA by spectrophotometry
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Bacteria |
| Confidence | 0 — Uncurated / Unknown |
| Curated By | Autocuration |
Publication
Protein Stability Effects in Aggregate-Based Enzyme Inhibition.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 4.72 | 5.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1160008 | IODOPHTHALEIN | 2.0 | 1 | 5.33 |
| CHEMBL1358 | FULVESTRANT | 4.0 | 1 | 4.11 |
| CHEMBL91 | MICONAZOLE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1160008 | IODOPHTHALEIN | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL1358 | FULVESTRANT | IC50 | = | 78400.0 | nM | 4.11 |
| CHEMBL91 | MICONAZOLE | IC50 | = | 130000.0 | nM | - |