Assay Detail
Functional
CHEMBL4416370
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Allosteric antagonist activity at human CB1 receptor by Ca2+ assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.09 | 7.64 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4078901 | — | — | 1 | 7.64 |
| CHEMBL3341861 | — | — | 1 | 7.48 |
| CHEMBL3341880 | — | — | 1 | 7.48 |
| CHEMBL4450500 | — | — | 1 | 6.77 |
| CHEMBL1553629 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4078901 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3341861 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL3341880 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4450500 | — | IC50 | = | 169.0 | nM | 6.77 |
| CHEMBL1553629 | — | IC50 | = | 853.0 | nM | 6.07 |