Assay Detail
Functional
CHEMBL4416374
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Allosteric modulator activity at human CB1 receptor expressed in CHO-RD-HGA16 cells co-expressing Galpha16 assessed as suppression of 100 nM CP55,940-induced calcium mobilization pre-incubated for 15 mins by Calcium 5 dye based FLIPR assay
31
Total Activities
31
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and Pharmacological Evaluation of 1-Phenyl-3-Thiophenylurea Derivatives as Cannabinoid Type-1 Receptor Allosteric Modulators.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 31 | 6.97 | 8.17 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4527602 | — | — | 1 | 8.17 |
| CHEMBL4464917 | — | — | 1 | 7.68 |
| CHEMBL4590582 | — | — | 1 | 7.66 |
| CHEMBL4584483 | — | — | 1 | 7.51 |
| CHEMBL3341861 | — | — | 1 | 7.48 |
| CHEMBL4528445 | — | — | 1 | 7.43 |
| CHEMBL4572697 | — | — | 1 | 7.41 |
| CHEMBL4544453 | — | — | 1 | 7.40 |
| CHEMBL4452850 | — | — | 1 | 7.40 |
| CHEMBL4565127 | — | — | 1 | 7.37 |
| CHEMBL4438047 | — | — | 1 | 7.32 |
| CHEMBL4442623 | — | — | 1 | 7.24 |
| CHEMBL4542852 | — | — | 1 | 7.22 |
| CHEMBL4513477 | — | — | 1 | 7.21 |
| CHEMBL4591294 | — | — | 1 | 7.10 |
| CHEMBL4581327 | — | — | 1 | 7.10 |
| CHEMBL4450625 | — | — | 1 | 7.05 |
| CHEMBL4474515 | — | — | 1 | 7.04 |
| CHEMBL4472252 | — | — | 1 | 6.97 |
| CHEMBL4580323 | — | — | 1 | 6.97 |
| CHEMBL4450873 | — | — | 1 | 6.96 |
| CHEMBL4443032 | — | — | 1 | 6.81 |
| CHEMBL4577814 | — | — | 1 | 6.63 |
| CHEMBL4539271 | — | — | 1 | 6.54 |
| CHEMBL4577767 | — | — | 1 | 6.46 |
| CHEMBL4554290 | — | — | 1 | 6.30 |
| CHEMBL4443540 | — | — | 1 | 5.91 |
| CHEMBL4542455 | — | — | 1 | 5.90 |
| CHEMBL4457227 | — | — | 1 | 5.45 |
| CHEMBL4475934 | — | — | 1 | 5.41 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4527602 | — | IC50 | = | 6.8 | nM | 8.17 |
| CHEMBL4464917 | — | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4590582 | — | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4584483 | — | IC50 | = | 31.0 | nM | 7.51 |
| CHEMBL3341861 | — | IC50 | = | 33.0 | nM | 7.48 |
| CHEMBL4528445 | — | IC50 | = | 37.0 | nM | 7.43 |
| CHEMBL4572697 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4544453 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4452850 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL4565127 | — | IC50 | = | 43.0 | nM | 7.37 |
| CHEMBL4438047 | — | IC50 | = | 48.0 | nM | 7.32 |
| CHEMBL4442623 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL4542852 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL4513477 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL4591294 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4581327 | — | IC50 | = | 79.0 | nM | 7.10 |
| CHEMBL4450625 | — | IC50 | = | 89.0 | nM | 7.05 |
| CHEMBL4474515 | — | IC50 | = | 92.0 | nM | 7.04 |
| CHEMBL4472252 | — | IC50 | = | 108.0 | nM | 6.97 |
| CHEMBL4580323 | — | IC50 | = | 107.0 | nM | 6.97 |
| CHEMBL4450873 | — | IC50 | = | 111.0 | nM | 6.96 |
| CHEMBL4443032 | — | IC50 | = | 156.0 | nM | 6.81 |
| CHEMBL4577814 | — | IC50 | = | 233.0 | nM | 6.63 |
| CHEMBL4539271 | — | IC50 | = | 292.0 | nM | 6.54 |
| CHEMBL4577767 | — | IC50 | = | 345.0 | nM | 6.46 |
| CHEMBL4554290 | — | IC50 | = | 501.0 | nM | 6.30 |
| CHEMBL4443540 | — | IC50 | = | 1220.0 | nM | 5.91 |
| CHEMBL4542455 | — | IC50 | = | 1270.0 | nM | 5.90 |
| CHEMBL4457227 | — | IC50 | = | 3530.0 | nM | 5.45 |
| CHEMBL4475934 | — | IC50 | = | 3880.0 | nM | 5.41 |
| CHEMBL4468436 | — | IC50 | > | 10000.0 | nM | - |