Assay Detail
Binding
CHEMBL4416859
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Inhibition of capsid in HBV infected in human HepG.2.2.15 cells assessed as reduction of HBV DNA incubated for 5 days by quantitative PCR analysis
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Hepatitis B virus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
A New Approach of Mitigating CYP3A4 Induction Led to the Discovery of Potent Hepatitis B Virus (HBV) Capsid Inhibitor with Optimal ADMET Profiles.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 22 | 8.07 | 8.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4587268 | — | — | 1 | 8.70 |
| CHEMBL4077913 | — | — | 1 | 8.70 |
| CHEMBL4064672 | — | — | 1 | 8.52 |
| CHEMBL4446995 | — | — | 1 | 8.52 |
| CHEMBL4577679 | — | — | 1 | 8.52 |
| CHEMBL4517178 | — | — | 1 | 8.30 |
| CHEMBL4580643 | — | — | 1 | 8.30 |
| CHEMBL4567962 | — | — | 1 | 8.00 |
| CHEMBL4447713 | — | — | 1 | 8.00 |
| CHEMBL4449828 | — | — | 1 | 8.00 |
| CHEMBL4452181 | — | — | 1 | 7.96 |
| CHEMBL4090739 | — | — | 1 | 7.85 |
| CHEMBL4465875 | — | — | 1 | 7.82 |
| CHEMBL4069741 | — | — | 1 | 7.82 |
| CHEMBL4452168 | — | — | 1 | 7.75 |
| CHEMBL4470025 | — | — | 1 | 7.66 |
| CHEMBL4462465 | — | — | 1 | 7.55 |
| CHEMBL4476494 | — | — | 1 | 7.34 |
| CHEMBL4459737 | — | — | 1 | - |
| CHEMBL4466969 | — | — | 1 | - |
| CHEMBL4451367 | — | — | 1 | - |
| CHEMBL4541951 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4587268 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4077913 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4064672 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4446995 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4577679 | — | EC50 | = | 3.0 | nM | 8.52 |
| CHEMBL4517178 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4580643 | — | EC50 | = | 5.0 | nM | 8.30 |
| CHEMBL4567962 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4447713 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4449828 | — | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4452181 | — | EC50 | = | 11.0 | nM | 7.96 |
| CHEMBL4090739 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL4465875 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4069741 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL4452168 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4470025 | — | EC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4462465 | — | EC50 | = | 28.0 | nM | 7.55 |
| CHEMBL4476494 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL4459737 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4466969 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4451367 | — | EC50 | > | 1000.0 | nM | - |
| CHEMBL4541951 | — | EC50 | - | — | - |