Assay Detail
Functional
CHEMBL4417010
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human A549 cells harbouring wild type EGFR incubated for 72 hrs by SRB assay
21
Total Activities
21
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | A549 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 21 | 5.23 | 5.34 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4588786 | — | — | 1 | 5.34 |
| CHEMBL4461616 | — | — | 1 | 5.33 |
| CHEMBL4437863 | — | — | 1 | 5.33 |
| CHEMBL4452906 | — | — | 1 | 5.32 |
| CHEMBL4522185 | — | — | 1 | 5.30 |
| CHEMBL4445469 | — | — | 1 | 5.28 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | — | 1 | 5.24 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.21 |
| CHEMBL4167113 | — | — | 1 | 5.21 |
| CHEMBL4548243 | — | — | 1 | 5.20 |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | 5.19 |
| CHEMBL4567629 | — | — | 1 | 5.04 |
| CHEMBL4537422 | — | — | 1 | 5.03 |
| CHEMBL4454172 | — | — | 1 | - |
| CHEMBL4460981 | — | — | 1 | - |
| CHEMBL4580121 | — | — | 1 | - |
| CHEMBL4470692 | — | — | 1 | - |
| CHEMBL4456487 | — | — | 1 | - |
| CHEMBL4585954 | — | — | 1 | - |
| CHEMBL4470531 | — | — | 1 | - |
| CHEMBL486400 | HEDERAGENIN | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4588786 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL4461616 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4437863 | — | IC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL4452906 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4522185 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4445469 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | IC50 | = | 5800.0 | nM | 5.24 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4167113 | — | IC50 | = | 6200.0 | nM | 5.21 |
| CHEMBL4548243 | — | IC50 | = | 6300.0 | nM | 5.20 |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | = | 6400.0 | nM | 5.19 |
| CHEMBL4567629 | — | IC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL4537422 | — | IC50 | = | 9300.0 | nM | 5.03 |
| CHEMBL4454172 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4460981 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4580121 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4470692 | — | IC50 | - | — | - | |
| CHEMBL4456487 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4585954 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4470531 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL486400 | HEDERAGENIN | IC50 | > | 10000.0 | nM | - |