Assay Detail
Functional
CHEMBL4417012
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human KB cells incubated for 72 hrs by SRB assay
22
Total Activities
22
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | KB |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of an Oleanolic Acid/Hederagenin-Nitric Oxide Donor Hybrid as an EGFR Tyrosine Kinase Inhibitor for Non-Small-Cell Lung Cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 22 | 5.22 | 5.32 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4461616 | — | — | 1 | 5.32 |
| CHEMBL4548243 | — | — | 1 | 5.31 |
| CHEMBL4437863 | — | — | 1 | 5.30 |
| CHEMBL4522185 | — | — | 1 | 5.29 |
| CHEMBL4588786 | — | — | 1 | 5.29 |
| CHEMBL4452906 | — | — | 1 | 5.28 |
| CHEMBL428647 | PACLITAXEL | 4.0 | 1 | 5.18 |
| CHEMBL4445469 | — | — | 1 | 5.16 |
| CHEMBL4167113 | — | — | 1 | 5.13 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | — | 1 | 5.12 |
| CHEMBL4580121 | — | — | 1 | 5.02 |
| CHEMBL486400 | HEDERAGENIN | — | 1 | - |
| CHEMBL4567629 | — | — | 1 | - |
| CHEMBL4470531 | — | — | 1 | - |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
| CHEMBL4585954 | — | — | 1 | - |
| CHEMBL4554092 | — | — | 1 | - |
| CHEMBL4456487 | — | — | 1 | - |
| CHEMBL4470692 | — | — | 1 | - |
| CHEMBL4454172 | — | — | 1 | - |
| CHEMBL4460981 | — | — | 1 | - |
| CHEMBL4537422 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4461616 | — | IC50 | = | 4800.0 | nM | 5.32 |
| CHEMBL4548243 | — | IC50 | = | 4900.0 | nM | 5.31 |
| CHEMBL4437863 | — | IC50 | = | 5000.0 | nM | 5.30 |
| CHEMBL4522185 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4588786 | — | IC50 | = | 5100.0 | nM | 5.29 |
| CHEMBL4452906 | — | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL428647 | PACLITAXEL | IC50 | = | 6600.0 | nM | 5.18 |
| CHEMBL4445469 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4167113 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL486822 | ACETYL OLEANOLIC ACID | IC50 | = | 7600.0 | nM | 5.12 |
| CHEMBL4580121 | — | IC50 | = | 9500.0 | nM | 5.02 |
| CHEMBL486400 | HEDERAGENIN | IC50 | > | 10000.0 | nM | - |
| CHEMBL4567629 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4470531 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 10000.0 | nM | - |
| CHEMBL4585954 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4554092 | — | IC50 | - | — | - | |
| CHEMBL4456487 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4470692 | — | IC50 | - | — | - | |
| CHEMBL4454172 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4460981 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL4537422 | — | IC50 | > | 10000.0 | nM | - |