Assay Detail
Binding
CHEMBL4417330
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant COX2 expressed in baculovirus infected sf21 cells assessed as decrease in PGE2 formation using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition measured after 45 mins by LC-MS analysis
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Sf21 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 7.35 | 7.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL29920 | — | — | 1 | 7.35 |
| CHEMBL455098 | beta-AMYRIN | — | 1 | - |
| CHEMBL461060 | — | — | 1 | - |
| CHEMBL489551 | — | — | 1 | - |
| CHEMBL4462866 | — | — | 1 | - |
| CHEMBL4566953 | — | — | 1 | - |
| CHEMBL4561483 | — | — | 1 | - |
| CHEMBL230006 | ENOXOLONE | 2.0 | 1 | - |
| CHEMBL487933 | — | — | 1 | - |
| CHEMBL400074 | ERYTHRODIOL | — | 1 | - |
| CHEMBL168 | OLEANOLIC_ACID | — | 1 | - |
| CHEMBL201515 | MASLINIC ACID | — | 1 | - |
| CHEMBL464466 | ARJUNOLIC ACID | — | 1 | - |
| CHEMBL486400 | HEDERAGENIN | — | 1 | - |
| CHEMBL1797308 | — | — | 1 | - |
| CHEMBL2386825 | — | — | 1 | - |
| CHEMBL520726 | — | — | 1 | - |
| CHEMBL395428 | — | — | 1 | - |
| CHEMBL1802044 | — | — | 1 | - |
| CHEMBL455357 | — | — | 1 | - |
| CHEMBL518475 | — | — | 1 | - |
| CHEMBL399873 | UVAOL | — | 1 | - |
| CHEMBL169 | URSOLIC ACID | 2.0 | 1 | - |
| CHEMBL391533 | COROSOLIC ACID | — | 1 | - |
| CHEMBL404313 | ASIATIC ACID | — | 1 | - |
| CHEMBL267225 | BOSWELLIC ACID | 2.0 | 1 | - |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | — | 1 | - |
| CHEMBL236906 | — | — | 1 | - |
| CHEMBL237111 | AKBA | -1.0 | 1 | - |
| CHEMBL2386654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL29920 | — | IC50 | = | 45.0 | nM | 7.35 |
| CHEMBL455098 | beta-AMYRIN | IC50 | - | — | - | |
| CHEMBL461060 | — | IC50 | - | — | - | |
| CHEMBL489551 | — | IC50 | - | — | - | |
| CHEMBL4462866 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4566953 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL4561483 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL230006 | ENOXOLONE | IC50 | > | 40000.0 | nM | - |
| CHEMBL487933 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL400074 | ERYTHRODIOL | IC50 | - | — | - | |
| CHEMBL168 | OLEANOLIC_ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL201515 | MASLINIC ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL464466 | ARJUNOLIC ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL486400 | HEDERAGENIN | IC50 | - | — | - | |
| CHEMBL1797308 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL2386825 | — | IC50 | - | — | - | |
| CHEMBL520726 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL395428 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL1802044 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL455357 | — | IC50 | - | — | - | |
| CHEMBL518475 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL399873 | UVAOL | IC50 | - | — | - | |
| CHEMBL169 | URSOLIC ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL391533 | COROSOLIC ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL404313 | ASIATIC ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL267225 | BOSWELLIC ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL437964 | 11-KETO BOSWELLIC ACID | IC50 | > | 40000.0 | nM | - |
| CHEMBL236906 | — | IC50 | > | 40000.0 | nM | - |
| CHEMBL237111 | AKBA | IC50 | > | 40000.0 | nM | - |
| CHEMBL2386654 | — | IC50 | - | — | - |