Assay Detail
Functional
CHEMBL4417520
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Antiproliferative activity against human NCI-H520 cells incubated for 48 hrs by MTT assay
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H520 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of 4,6-pyrimidinediamine derivatives as novel dual EGFR/FGFR inhibitors aimed EGFR/FGFR1-positive NSCLC.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 5.19 | 5.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4548481 | — | — | 1 | 5.52 |
| CHEMBL4537004 | — | — | 1 | 5.42 |
| CHEMBL4440779 | — | — | 1 | 5.35 |
| CHEMBL4581382 | — | — | 1 | 5.12 |
| CHEMBL4464085 | — | — | 1 | 5.01 |
| CHEMBL4439933 | — | — | 1 | 4.98 |
| CHEMBL4554805 | — | — | 1 | 4.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4548481 | — | IC50 | = | 3030.0 | nM | 5.52 |
| CHEMBL4537004 | — | IC50 | = | 3780.0 | nM | 5.42 |
| CHEMBL4440779 | — | IC50 | = | 4450.0 | nM | 5.35 |
| CHEMBL4581382 | — | IC50 | = | 7520.0 | nM | 5.12 |
| CHEMBL4464085 | — | IC50 | = | 9870.0 | nM | 5.01 |
| CHEMBL4439933 | — | IC50 | = | 10460.0 | nM | 4.98 |
| CHEMBL4554805 | — | IC50 | = | 10840.0 | nM | 4.96 |