Assay Detail
Binding
CHEMBL4417801
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of RGS17 (unknown origin) assessed as reduction in RGS17 interaction with 6x-his-tagged biotinylated Galpha-o interaction by Alpha-screen assay
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Regulator of G-protein signaling 17 (CHEMBL4295974) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutic compounds and methods
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 4 | - | - |
| IC50 | 4 | 5.48 | 6.37 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1438439 | IRIGENOL | — | 2 | 6.37 |
| CHEMBL490129 | SANGUINARIUM CHLORIDE | 2.0 | 2 | 5.86 |
| CHEMBL555017 | GAMBOGIC ACID | — | 2 | 4.91 |
| CHEMBL301982 | CELASTROL | — | 2 | 4.77 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1438439 | IRIGENOL | IC50 | = | 423.2 | nM | 6.37 |
| CHEMBL490129 | SANGUINARIUM CHLORIDE | IC50 | = | 1386.0 | nM | 5.86 |
| CHEMBL555017 | GAMBOGIC ACID | IC50 | = | 12260.0 | nM | 4.91 |
| CHEMBL301982 | CELASTROL | IC50 | = | 16810.0 | nM | 4.77 |
| CHEMBL490129 | SANGUINARIUM CHLORIDE | Inhibition | - | % | - | |
| CHEMBL301982 | CELASTROL | Inhibition | - | % | - | |
| CHEMBL555017 | GAMBOGIC ACID | Inhibition | - | % | - | |
| CHEMBL1438439 | IRIGENOL | Inhibition | - | % | - |