Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL4417816

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to full-length recombinant human CYP46A1 by spectral binding study
10
Total Activities
10
Compounds Tested
2
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Cholesterol 24-hydroxylase (CHEMBL4523510)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Post-Translational Regulation of Catalytic Activities of Cytochrome P450 46A1 and Uses Thereof
(2017)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 9 6.92 7.30
Activity 1 - -

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL1231592 1 7.30
CHEMBL638 VORICONAZOLE 4.0 1 7.30
CHEMBL112570 CHOLESTEROL 2.0 1 6.17
CHEMBL1628111 1 -
CHEMBL253363 PREGNENOLONE 1.0 1 -
CHEMBL4463070 1 -
CHEMBL386630 TESTOSTERONE 4.0 1 -
CHEMBL135 ESTRADIOL 4.0 1 -
CHEMBL90593 PRASTERONE 4.0 1 -
CHEMBL4471928 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL1231592 Kd = 50.0 nM 7.30
CHEMBL638 VORICONAZOLE Kd = 50.0 nM 7.30
CHEMBL112570 CHOLESTEROL Kd = 670.0 nM 6.17
CHEMBL1628111 Kd - -
CHEMBL253363 PREGNENOLONE Activity - -
CHEMBL4463070 Kd - -
CHEMBL386630 TESTOSTERONE Kd - -
CHEMBL135 ESTRADIOL Kd - -
CHEMBL90593 PRASTERONE Kd - -
CHEMBL4471928 Kd - -