Assay Detail
Binding
CHEMBL4417865
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of full length DUSP5 (unknown origin) assessed as reduction in de-phosphorylation of GST-tagged recombinant phosphorylated ERK2 incubated for 15 mins by SDS-PAGE based immunoblot assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Dual specificity protein phosphatase 5 (CHEMBL1250380) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small molecule antagonists of dusp5 and methods of use
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 6.79 | 6.79 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL590572 | — | — | 1 | 6.79 |
| CHEMBL316894 | — | — | 1 | - |
| CHEMBL4442649 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL590572 | — | IC50 | = | 161.0 | nM | 6.79 |
| CHEMBL316894 | — | IC50 | = | 221000.0 | nM | - |
| CHEMBL4442649 | — | IC50 | > | 1000000.0 | nM | - |