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Assay Detail

CHEMBL4417894

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of RAD52 (unknown origin) assessed as effect on ssDNA annealing using ssDNA oligonucleotide by fluorescence-quenching assay
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

DNA repair protein RAD52 homolog (CHEMBL2362978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Inhibitors of RAD52 Recombination Protein and Methods Using Same
(2018)

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 17 5.42 5.77

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL4522859 1 5.77
CHEMBL1544647 1 5.70
CHEMBL3186644 1 5.70
CHEMBL1325721 1 5.70
CHEMBL1389885 1 5.55
CHEMBL3189128 1 5.54
CHEMBL1389728 1 5.46
CHEMBL1373317 1 5.44
CHEMBL3185804 1 5.39
CHEMBL1198365 1 5.37
CHEMBL4463510 1 5.32
CHEMBL1573779 1 5.28
CHEMBL3303124 1 5.25
CHEMBL606456 1 5.22
CHEMBL1428009 1 5.22
CHEMBL596633 1 5.17
CHEMBL1514131 1 5.01

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL4522859 IC50 = 1700.0 nM 5.77
CHEMBL1544647 IC50 = 2000.0 nM 5.70
CHEMBL3186644 IC50 = 2000.0 nM 5.70
CHEMBL1325721 IC50 = 2000.0 nM 5.70
CHEMBL1389885 IC50 = 2800.0 nM 5.55
CHEMBL3189128 IC50 = 2900.0 nM 5.54
CHEMBL1389728 IC50 = 3500.0 nM 5.46
CHEMBL1373317 IC50 = 3600.0 nM 5.44
CHEMBL3185804 IC50 = 4100.0 nM 5.39
CHEMBL1198365 IC50 = 4300.0 nM 5.37
CHEMBL4463510 IC50 = 4800.0 nM 5.32
CHEMBL1573779 IC50 = 5200.0 nM 5.28
CHEMBL3303124 IC50 = 5600.0 nM 5.25
CHEMBL606456 IC50 = 6000.0 nM 5.22
CHEMBL1428009 IC50 = 6000.0 nM 5.22
CHEMBL596633 IC50 = 6800.0 nM 5.17
CHEMBL1514131 IC50 = 9800.0 nM 5.01