Assay Detail
Binding
CHEMBL4417922
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of Rac1 in human MDA-MB-435 cells incubated for 24 hrs by G-LISA Rac1 activation assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-435 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Ras-related C3 botulinum toxin substrate 1 (CHEMBL6094) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Small-molecule inhibitors of Rac1 in metastatic breast cancer
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.99 | 5.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3237589 | — | — | 1 | 5.96 |
| CHEMBL1535331 | — | — | 1 | 4.02 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3237589 | — | IC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL1535331 | — | IC50 | = | 95000.0 | nM | 4.02 |