Assay Detail
Binding
CHEMBL4418508
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant FLAG-tagged EML4-ALK fusion protein (unknown origin) expressed in mouse BA/F3 cells assessed as inhibition of cell growth incubated for 2 days by alamar blue dye based assay
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Diamino heterocyclic carboxamide compound
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 43 | 7.80 | 8.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3687205 | — | — | 1 | 8.39 |
| CHEMBL3687223 | — | — | 1 | 8.33 |
| CHEMBL3687200 | — | — | 1 | 8.31 |
| CHEMBL3301622 | GILTERITINIB | 4.0 | 1 | 8.24 |
| CHEMBL3889838 | — | — | 1 | 8.23 |
| CHEMBL3687202 | — | — | 1 | 8.21 |
| CHEMBL3687207 | — | — | 1 | 8.20 |
| CHEMBL3687206 | — | — | 1 | 8.19 |
| CHEMBL3687201 | — | — | 1 | 8.16 |
| CHEMBL3687217 | — | — | 1 | 8.11 |
| CHEMBL3687211 | — | — | 1 | 8.09 |
| CHEMBL3687197 | — | — | 1 | 8.07 |
| CHEMBL3687198 | — | — | 1 | 8.04 |
| CHEMBL3687212 | — | — | 1 | 8.03 |
| CHEMBL3687193 | — | — | 1 | 8.02 |
| CHEMBL3687209 | — | — | 1 | 8.01 |
| CHEMBL3687204 | — | — | 1 | 8.00 |
| CHEMBL4572977 | — | — | 1 | 7.96 |
| CHEMBL3687210 | — | — | 1 | 7.96 |
| CHEMBL3687195 | — | — | 1 | 7.96 |
| CHEMBL3687194 | — | — | 1 | 7.96 |
| CHEMBL3687224 | — | — | 1 | 7.85 |
| CHEMBL3687221 | — | — | 1 | 7.85 |
| CHEMBL3687225 | — | — | 1 | 7.80 |
| CHEMBL4582572 | — | — | 1 | 7.80 |
| CHEMBL3975354 | — | — | 1 | 7.77 |
| CHEMBL4530476 | — | — | 1 | 7.75 |
| CHEMBL4518930 | — | — | 1 | 7.72 |
| CHEMBL3687215 | — | — | 1 | 7.72 |
| CHEMBL3687191 | — | — | 1 | 7.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3687205 | — | IC50 | = | 4.1 | nM | 8.39 |
| CHEMBL3687223 | — | IC50 | = | 4.7 | nM | 8.33 |
| CHEMBL3687200 | — | IC50 | = | 4.9 | nM | 8.31 |
| CHEMBL3301622 | GILTERITINIB | IC50 | = | 5.7 | nM | 8.24 |
| CHEMBL3889838 | — | IC50 | = | 5.9 | nM | 8.23 |
| CHEMBL3687202 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL3687207 | — | IC50 | = | 6.3 | nM | 8.20 |
| CHEMBL3687206 | — | IC50 | = | 6.5 | nM | 8.19 |
| CHEMBL3687201 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL3687217 | — | IC50 | = | 7.7 | nM | 8.11 |
| CHEMBL3687211 | — | IC50 | = | 8.1 | nM | 8.09 |
| CHEMBL3687197 | — | IC50 | = | 8.6 | nM | 8.07 |
| CHEMBL3687198 | — | IC50 | = | 9.2 | nM | 8.04 |
| CHEMBL3687212 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL3687193 | — | IC50 | = | 9.5 | nM | 8.02 |
| CHEMBL3687209 | — | IC50 | = | 9.8 | nM | 8.01 |
| CHEMBL3687204 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL4572977 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3687210 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3687195 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3687194 | — | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL3687224 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3687221 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL3687225 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL4582572 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL3975354 | — | IC50 | = | 17.0 | nM | 7.77 |
| CHEMBL4530476 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL4518930 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3687215 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL3687191 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL3687220 | — | IC50 | = | 23.0 | nM | 7.64 |
| CHEMBL3687216 | — | IC50 | = | 24.0 | nM | 7.62 |
| CHEMBL3687219 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL3687218 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL3687222 | — | IC50 | = | 39.0 | nM | 7.41 |
| CHEMBL4577509 | — | IC50 | = | 42.0 | nM | 7.38 |
| CHEMBL3687199 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL3687189 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL3687188 | — | IC50 | = | 68.0 | nM | 7.17 |
| CHEMBL3687192 | — | IC50 | = | 76.0 | nM | 7.12 |
| CHEMBL3687190 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL4456322 | — | IC50 | = | 821.0 | nM | 6.09 |
| CHEMBL4585232 | — | IC50 | > | 1000.0 | nM | - |