Assay Detail
Binding
CHEMBL4418828
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human recombinant ENTPD5 expressed in insect cells assessed as reduction in UDP hydrolysis incubated for 1 hr in presence of UMP, GTP and ATP by Escherichia coli UMP kinase pyrH catalyzed UMP phosphorylation coupled luciferase assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nucleoside diphosphate phosphatase ENTPD5 (CHEMBL4523151) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Entpd5 inhibitors
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 4.72 | 5.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1736978 | — | — | 1 | 5.00 |
| CHEMBL504264 | AUREOL | — | 1 | 4.82 |
| CHEMBL4457743 | — | — | 1 | 4.52 |
| CHEMBL4530054 | — | — | 1 | 4.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1736978 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL504264 | AUREOL | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL4457743 | — | IC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL4530054 | — | IC50 | = | 30000.0 | nM | 4.52 |